Key milestones of lipid nanoparticle (LNP) development

1965

Development of liposomes

1978

Development of liposome–mRNA formulations

1989

Development of cationic LNP–mRNA formulations

1993

Development of liposome–mRNA formulations as influenza vaccine

1995

LNPs encapsulating small molecules (doxorubicin or amphotericin B) were approved by the FDA

1996

LNPs encapsulating daunorubicin were approved by the FDA and the EMA

2000

LNPs encapsulating verteporfin were approved by the FDA

2012

LNPs encapsulating vincristine were approved by the FDA

2014

Clinical trial of LNP–mRNA formulations for cancer immunotherapies (NCT02316457)

2015

SyVento BioTech is founded with a commitment to develop lipid-based drug delivery systems. Leveraging their experience and expertise, the company focuses on creating innovative and effective lipid nanoparticle solutions for RNA-based medicine

2017

• Clinical trial of LNP–mRNA formulations as influenza vaccines (NCT03076385)
• Clinical trial of LNP–mRNA formulationsfor protein replacement therapies (NCT03375047)
• First in-human test of personalized mRNA cancer vaccines

2018

Onpattro (LNPs encapsulating siRNA), the first siRNA drug, was approved by the FDA and the EMA

2020

• mRNA-1273 and BNT162b (LNP–mRNA formulations) COVID-19 mRNA vaccines obtained authorization from regulatory agencies in multiple countries
• Clinical trial of LNP formulations delivering gene-editing components for genetic disorders (NCT04601051)

2021

SyVento and OncoArendi (currently Molecure) sign a joint development collaboration and exclusive global licensing agreement for the use of the nanoliposomal formulation of the arginase inhibitor OATD-02, further solidifying SyVento's reputation in the field

2023

SyVento BioTech opens its state-of-the-art R&D facility, expanding its research capabilities in lipid-based drug delivery systems and RNA-based medicine. This advanced research and production facility distinguishes the company as a standout in this part of the world, reflecting its commitment to innovation and excellence

Xucheng Hou, Tal Zaks, Robert Langer, Yizhou Dong. ” Lipid nanoparticles for mRNA delivery.” Nature Reviews Materials volume 6, (2021): pages1078–1094. https://doi.org/10.1038/s41578-021-00358-0

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